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The effects of denosumab and alendronate on glucocorticoid-induced osteoporosis in patients with glomerular disease: A randomized, controlled trial

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Listed:
  • Ken Iseri
  • Masayuki Iyoda
  • Makoto Watanabe
  • Kei Matsumoto
  • Daisuke Sanada
  • Takashi Inoue
  • Shohei Tachibana
  • Takanori Shibata

Abstract

Introduction: The clinical utility of denosumab for the treatment of glucocorticoid-induced osteoporosis (GIOP) has yet to be established. This study aimed to compare the effects of denosumab on bone mineral density (BMD) and bone turnover markers to those of alendronate in patients with GIOP. Methods: A prospective, single-center study of 32 patients (18 men; median age, 66.0 years) with glomerular disease receiving prednisolone (PSL) who were diagnosed as having GIOP and had not received bisphosphonates before was conducted. Participants were randomized to either alendronate (35 mg orally once a week) or denosumab (60 mg subcutaneously once every 6 months), and all subjects received calcitriol. The primary endpoint was the percent change in lumbar spine (LS) BMD at 12 months of treatment. Results: The demographic and clinical characteristics at baseline were not significantly different between the groups. Denosumab treatment markedly decreased serum levels of t-PINP, BAP, and TRACP-5b at 12 months compared to baseline (-57.4%, p

Suggested Citation

  • Ken Iseri & Masayuki Iyoda & Makoto Watanabe & Kei Matsumoto & Daisuke Sanada & Takashi Inoue & Shohei Tachibana & Takanori Shibata, 2018. "The effects of denosumab and alendronate on glucocorticoid-induced osteoporosis in patients with glomerular disease: A randomized, controlled trial," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0193846
    DOI: 10.1371/journal.pone.0193846
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