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Peptidylarginine deiminase 4 -104C/T polymorphism and risk of rheumatoid arthritis: A pooled analysis based on different populations

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  • Jiong Hua
  • Weijie Huang

Abstract

Background: Many studies have analyzed the association between peptidylarginine deiminase 4 (PADI4) -104C/T polymorphism and rheumatoid arthritis (RA). However, the results are inconsistent. This meta-analysis, based on different populations, updated and reevaluated the possible associations between PADI4 -104C/T polymorphism and the susceptibility to RA. Methods: A literature search was performed on PubMed and related Chinese databases up to April 2017. The association between PADI4 -104C/T polymorphism and RA risk was evaluated by calculating pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of seventeen studies, including 5,756 RA cases and 4,987 controls, were screened out. In the overall population, PADI -104C/T polymorphism was significantly associated with an increased RA risk. In this meta-analysis stratified by ethnicity, a significant association between PADI -104C/T polymorphism and RA risk was established in China and Japan. Conclusions: Our study indicated a significantly increased association between PADI -104C/T polymorphism and RA in Chinese and Japanese populations. Because most included populations in this meta-analysis were Asian, further studies are needed to elucidate whether the PADI4 -104C/T gene confers RA in other ethnic groups.

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  • Jiong Hua & Weijie Huang, 2018. "Peptidylarginine deiminase 4 -104C/T polymorphism and risk of rheumatoid arthritis: A pooled analysis based on different populations," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0193674
    DOI: 10.1371/journal.pone.0193674
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    Cited by:

    1. Hang Su & Na Rei & Lei Zhang & Jiaxiang Cheng, 2018. "Meta-analyses of IL1A polymorphisms and the risk of several autoimmune diseases published in databases," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-18, June.

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