IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0192910.html
   My bibliography  Save this article

The impact of “Option B” on HIV transmission from mother to child in Rwanda: An interrupted time series analysis

Author

Listed:
  • Monique Abimpaye
  • Catherine M Kirk
  • Hari S Iyer
  • Neil Gupta
  • Eric Remera
  • Placidie Mugwaneza
  • Michael R Law

Abstract

Background: Nearly a quarter of a million children have acquired HIV, prompting the implementation of new protocols—Option B and B+—for treating HIV+ pregnant women. While efficacy has been demonstrated in randomized trials, there is limited real-world evidence on the impact of these changes. Using longitudinal, routinely collected data we assessed the impact of the adoption of WHO Option B in Rwanda on mother to infant transmission. Methods: We used interrupted time series analysis to evaluate the impact of Option B on mother-to-child HIV transmission in Rwanda. Our primary outcome was the proportion of HIV tests in infants with positive results at six weeks of age. We included data for 20 months before and 22 months after the 2010 policy change. Results: Of the 15,830 HIV tests conducted during our study period, 392 tested positive. We found a significant decrease in both the level (-2.08 positive tests per 100 tests conducted, 95% CI: -2.71 to -1.45, p

Suggested Citation

  • Monique Abimpaye & Catherine M Kirk & Hari S Iyer & Neil Gupta & Eric Remera & Placidie Mugwaneza & Michael R Law, 2018. "The impact of “Option B” on HIV transmission from mother to child in Rwanda: An interrupted time series analysis," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-7, February.
    • Handle: RePEc:plo:pone00:0192910
    DOI: 10.1371/journal.pone.0192910
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192910
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0192910&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0192910?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Olufunke Fasawe & Carlos Avila & Nathan Shaffer & Erik Schouten & Frank Chimbwandira & David Hoos & Olive Nakakeeto & Paul De Lay, 2013. "Cost-Effectiveness Analysis of Option B+ for HIV Prevention and Treatment of Mothers and Children in Malawi," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-10, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Masiano, Steven P. & Kawende, Bienvenu & Ravelomanana, Noro Lantoniaina Rosa & Green, Tiffany L. & Dahman, Bassam & Thirumurthy, Harsha & Kimmel, April D. & Yotebieng, Marcel, 2023. "Economic costs and cost-effectiveness of conditional cash transfers for the uptake of services for the prevention of vertical HIV transmissions in a resource-limited setting," Social Science & Medicine, Elsevier, vol. 320(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0192910. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.