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Insulin resistance in lean and overweight non-diabetic Caucasian adults: Study of its relationship with liver triglyceride content, waist circumference and BMI

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Listed:
  • Jorge Gonzalez-Cantero
  • Jose Luis Martin-Rodriguez
  • Alvaro Gonzalez-Cantero
  • Juan Pedro Arrebola
  • Jorge Luis Gonzalez-Calvin

Abstract

Aims: Insulin resistance is the pathophysiological precursor of type 2 diabetes mellitus (DM-2), and its relationship with non-alcoholic fatty liver disease (NAFLD) has been widely studied in patients with obesity or metabolic syndrome using not only ultrasound but also liver biopsies or proton magnetic resonance spectroscopy (H1-MRS) to assess liver fat content. In contrast, there are no studies on insulin resistance and NAFLD in lean or overweight Caucasian individuals using H1-MRS or liver biopsies for the quantification of hepatic triglyceride content. Our objectives were to study the presence of insulin resistance in lean and overweight Caucasian adults and investigate its possible relationship with liver triglyceride content, waist circumference (as proxy of visceral adiposity), BMI, and cardiometabolic risk factors. Methods: A cross-sectional study was conducted in 113 non-obese, non-diabetic individuals classified as overweight (BMI 25–29.9 kg/m2) or lean (BMI 19.5–24.9 kg/m2). Hepatic triglyceride content was quantified by 3T H1-MRS. NAFLD was defined as hepatic triglyceride content >5.56%. Insulin resistance (HOMA-IR), serum adiponectin, and tumor necrosis factor (TNF) were determined. Results: HOMA-IR was significantly correlated with hepatic triglyceride content (r:0.76; p

Suggested Citation

  • Jorge Gonzalez-Cantero & Jose Luis Martin-Rodriguez & Alvaro Gonzalez-Cantero & Juan Pedro Arrebola & Jorge Luis Gonzalez-Calvin, 2018. "Insulin resistance in lean and overweight non-diabetic Caucasian adults: Study of its relationship with liver triglyceride content, waist circumference and BMI," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0192663
    DOI: 10.1371/journal.pone.0192663
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