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Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance

Author

Listed:
  • Minoru Iwata
  • Kazuo Hara
  • Yutaka Kamura
  • Hisae Honoki
  • Shiho Fujisaka
  • Manabu Ishiki
  • Isao Usui
  • Kunimasa Yagi
  • Yasuo Fukushima
  • Atsuko Takano
  • Hiromi Kato
  • Shihou Murakami
  • Kiyohiro Higuchi
  • Chikaaki Kobashi
  • Kazuhito Fukuda
  • Yukiko Koshimizu
  • Kazuyuki Tobe

Abstract

Aim: Among the three adiponectin isoforms, a lower ratio of high molecular weight (HMW) adiponectin to total adiponectin (TA) is well known to cause insulin resistance and type 2 diabetes (T2D). However, how the levels of other adiponectin isoforms, such as the middle molecular weight (MMW) and low molecular weight (LMW) isoforms, and their relative ratio to TA change in T2D subjects has not been determined. Therefore, we investigated the association of these adiponectin-related parameters with T2D. Methods: We examined the associations between adiponectin-related parameters and diabetes in a group of 394 T2D subjects and 374 controls (1st group) randomly selected from among the participants in our previous study. The associations between these parameters and the HOMA-IR in a 2nd group, consisting of the subjects remaining in the 1st group after the exclusion of subjects receiving diabetic medication, were also examined. Result: In the 1st group, after adjusting for confounding factor, the levels of all the adiponectin isoforms and the HMW/TA ratio were significantly lower among the diabetic subjects than among the controls (all P values

Suggested Citation

  • Minoru Iwata & Kazuo Hara & Yutaka Kamura & Hisae Honoki & Shiho Fujisaka & Manabu Ishiki & Isao Usui & Kunimasa Yagi & Yasuo Fukushima & Atsuko Takano & Hiromi Kato & Shihou Murakami & Kiyohiro Higuc, 2018. "Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0192609
    DOI: 10.1371/journal.pone.0192609
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