IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0192124.html
   My bibliography  Save this article

Computer tomography-based body surface area evaluation for drug dosage: Quantitative radiology versus anthropomorphic evaluation

Author

Listed:
  • Antoine Iannessi
  • Hubert Beaumont
  • Christophe Hebert
  • Claire Dittlot
  • Marie Noëlle Falewee

Abstract

Objective: The measure of body surface area (BSA) is a standard for planning optimal dosing in oncology. This index is derived from a model having questionable performances. In this study, we proposed measurement of BSA from whole body CT images (iBSA). We tested the reliability of iBSA assessments and simulated the impact of our approach on patient chemotherapy dosage planning. Methods: We first evaluated accuracy and precision of iBSA in measuring 14 phantom and 11 CT test-retest images.Secondly, we retrospectively analyzed 26 whole body PET-CT scans to evaluate inter-method variability between iBSA and the most used anthropomorphic models, notably the “Du Bois and Du Bois” model. Finally, we simulated the impact on chemotherapy dose planning of capecitabine based on iBSA. Results: Precision and accuracy of iBSA measurement featured a standard deviation of 1.11% and a mean error of 1.53%. Inter-method variability between iBSA and “Du Bois and Du Bois” assessment featured a standard deviation of 4.11% leading to a reclassification rate of capecitabine of 32.5%. Conclusions: iBSA could help the oncologist in standardizing assessments for chemotherapy planning. iBSA could also be relevant for applications such as comprehensive body composition and provide a sensitive measurement for changes related to nutritional intake or other metabolism.

Suggested Citation

  • Antoine Iannessi & Hubert Beaumont & Christophe Hebert & Claire Dittlot & Marie Noëlle Falewee, 2018. "Computer tomography-based body surface area evaluation for drug dosage: Quantitative radiology versus anthropomorphic evaluation," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0192124
    DOI: 10.1371/journal.pone.0192124
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192124
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0192124&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0192124?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0192124. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.