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Long-term clinical, immunological and virological outcomes of patients on antiretroviral therapy in southern Myanmar

Author

Listed:
  • Elkin Hernán Bermúdez-Aza
  • Sharmila Shetty
  • Janet Ousley
  • Nang Thu Thu Kyaw
  • Theint Thida Soe
  • Kyipyar Soe
  • Phyu Ei Mon
  • Kyaw Tin Tun
  • Iza Ciglenecki
  • Susanna Cristofani
  • Marcelo Fernandez

Abstract

Objective: To study the long-term clinical, immunological and virological outcomes among people living with HIV on antiretroviral therapy (ART) in Myanmar. Methods: A retrospective analysis of people on ART for >9 years followed by a cross-sectional survey among the patients in this group who remained on ART at the time of the survey. Routinely collected medical data established the baseline clinical and demographic characteristics for adult patients initiating ART between 2004 and 2006. Patients remaining on ART between March-August 2015 were invited to participate in a survey assessing clinical, virological, immunological, and biochemical characteristics. Results: Of 615 patients included in the retrospective analysis, 35 (6%) were lost-to-follow-up, 9 (1%) were transferred, 153 died (25%) and 418 (68%) remained active in care. Among deaths, 48 (31.4%) occurred within 3 months of ART initiation, and 81 (52.9%) within 12 months, 90.1% (n = 73) of which were initially classified as stage 3/4. Of 385 patients included in the survey, 30 (7.7%) were on second-line ART regimen; 373 (96.8%) had suppressed viral load (

Suggested Citation

  • Elkin Hernán Bermúdez-Aza & Sharmila Shetty & Janet Ousley & Nang Thu Thu Kyaw & Theint Thida Soe & Kyipyar Soe & Phyu Ei Mon & Kyaw Tin Tun & Iza Ciglenecki & Susanna Cristofani & Marcelo Fernandez, 2018. "Long-term clinical, immunological and virological outcomes of patients on antiretroviral therapy in southern Myanmar," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0191695
    DOI: 10.1371/journal.pone.0191695
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