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Prognostic value of presepsin in adult patients with sepsis: Systematic review and meta-analysis

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  • Hyun Suk Yang
  • Mina Hur
  • Ahram Yi
  • Hanah Kim
  • Seungho Lee
  • Soo-Nyung Kim

Abstract

Objective: Presepsin is a novel biomarker to diagnose sepsis but its prognostic value has not been comprehensively reviewed. We conducted this meta-analysis to evaluate the mortality prediction value of presepsin in sepsis. Methods: We searched comprehensive electronic databases from PubMed, EMBASE, and Cochrane Library through September 2017 using the key words of (‘presepsin’ or ‘sCD14-ST’ or ‘soluble CD14 subtype’) and (‘sepsis’ or ‘septic shock’) and (‘prognosis’ or ‘prognostic value’ or ‘prognostic biomarker’ or ‘mortality’). We extracted the presepsin levels in survivors and non-survivors from each individual study and evaluated the standardized mean difference (SMD) using a web-based meta-analysis with the R statistical analysis program. Results: A total of 10 studies and 1617 patients were included. Presepsin levels in the first sampling (within 24 hours) were significantly lower among survivors as compared with non-survivors: the pooled SMD between survivors and non-survivors was 0.92 (95% CI: 0.62–1.22) in the random effects model (I2 = 79%, P

Suggested Citation

  • Hyun Suk Yang & Mina Hur & Ahram Yi & Hanah Kim & Seungho Lee & Soo-Nyung Kim, 2018. "Prognostic value of presepsin in adult patients with sepsis: Systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0191486
    DOI: 10.1371/journal.pone.0191486
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    References listed on IDEAS

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    1. Dan Liu & Longxiang Su & Gencheng Han & Peng Yan & Lixin Xie, 2015. "Prognostic Value of Procalcitonin in Adult Patients with Sepsis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-15, June.
    2. Jiayuan Wu & Liren Hu & Gaohua Zhang & Fenping Wu & Taiping He, 2015. "Accuracy of Presepsin in Sepsis Diagnosis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-15, July.
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