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The impact of persistent bacterial bronchitis on the pulmonary microbiome of children

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  • Leah Cuthbertson
  • Vanessa Craven
  • Lynne Bingle
  • William O C M Cookson
  • Mark L Everard
  • Miriam F Moffatt

Abstract

Introduction: Persistent bacterial bronchitis (PBB) is a leading cause of chronic wet cough in young children. This study aimed to characterise the respiratory bacterial microbiota of healthy children and to assess the impact of the changes associated with the development of PBB. Results: No significant difference in bacterial diversity or community composition (R2 = 0.01, P = 0.36) was observed between paired blind and non-blind brushes, showing that blind brushings are a valid means of accessing the airway microbiota. This has important implications for collecting lower respiratory samples from healthy children. A significant decrease in bacterial diversity (P

Suggested Citation

  • Leah Cuthbertson & Vanessa Craven & Lynne Bingle & William O C M Cookson & Mark L Everard & Miriam F Moffatt, 2017. "The impact of persistent bacterial bronchitis on the pulmonary microbiome of children," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0190075
    DOI: 10.1371/journal.pone.0190075
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