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Left atrial voltage, circulating biomarkers of fibrosis, and atrial fibrillation ablation. A prospective cohort study

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Listed:
  • Gordon A Begg
  • Rashed Karim
  • Tobias Oesterlein
  • Lee N Graham
  • Andrew J Hogarth
  • Stephen P Page
  • Christopher B Pepper
  • Kawal Rhode
  • Gregory Y H Lip
  • Arun V Holden
  • Sven Plein
  • Muzahir H Tayebjee

Abstract

Aims: To test the ability of four circulating biomarkers of fibrosis, and of low left atrial voltage, to predict recurrence of atrial fibrillation after catheter ablation. Background: Circulating biomarkers potentially may be used to improve patient selection for atrial fibrillation ablation. Low voltage areas in the left atrium predict arrhythmia recurrence when mapped in sinus rhythm. This study tested type III procollagen N terminal peptide (PIIINP), galectin-3 (gal-3), fibroblast growth factor 23 (FGF-23), and type I collagen C terminal telopeptide (ICTP), and whether low voltage areas in the left atrium predicted atrial fibrillation recurrence, irrespective of the rhythm during mapping. Methods: 92 atrial fibrillation ablation patients were studied. Biomarker levels in peripheral and intra-cardiac blood were measured with enzyme-linked immunosorbent assay. Low voltage (

Suggested Citation

  • Gordon A Begg & Rashed Karim & Tobias Oesterlein & Lee N Graham & Andrew J Hogarth & Stephen P Page & Christopher B Pepper & Kawal Rhode & Gregory Y H Lip & Arun V Holden & Sven Plein & Muzahir H Taye, 2018. "Left atrial voltage, circulating biomarkers of fibrosis, and atrial fibrillation ablation. A prospective cohort study," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-13, January.
    • Handle: RePEc:plo:pone00:0189936
    DOI: 10.1371/journal.pone.0189936
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