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Supine posture changes lung volumes and increases ventilation heterogeneity in cystic fibrosis

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  • Laurie J Smith
  • Kenneth A Macleod
  • Guilhem J Collier
  • Felix C Horn
  • Helen Sheridan
  • Ina Aldag
  • Chris J Taylor
  • Steve Cunningham
  • Jim M Wild
  • Alex Horsley

Abstract

Introduction: Lung Clearance Index (LCI) is recognised as an early marker of cystic fibrosis (CF) lung disease. The effect of posture on LCI however is important when considering longitudinal measurements from infancy and when comparing LCI to imaging studies. Methods: 35 children with CF and 28 healthy controls (HC) were assessed. Multiple breath washout (MBW) was performed both sitting and supine in triplicate and analysed for LCI, Scond, Sacin, and lung volumes. These values were also corrected for the Fowler dead-space to create ‘alveolar’ indices. Results: From sitting to supine there was a significant increase in LCI and a significant decrease in FRC for both CF and HC (p

Suggested Citation

  • Laurie J Smith & Kenneth A Macleod & Guilhem J Collier & Felix C Horn & Helen Sheridan & Ina Aldag & Chris J Taylor & Steve Cunningham & Jim M Wild & Alex Horsley, 2017. "Supine posture changes lung volumes and increases ventilation heterogeneity in cystic fibrosis," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-12, November.
    • Handle: RePEc:plo:pone00:0188275
    DOI: 10.1371/journal.pone.0188275
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