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Prognostic value of pretreatment serum carbohydrate antigen 19-9 level in patients with colorectal cancer: A meta-analysis

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  • Zhan Yu
  • Zhen Chen
  • Jian Wu
  • Zhong Li
  • Yugang Wu

Abstract

Background: Carbohydrate antigen 19–9 (CA 19–9) is one of the most frequently used tumor markers for gastrointestinal cancer, particularly for diagnostic purposes. However, its value in predicting prognosis remains controversial. In this study, we sought to clarify this by conducting a meta-analysis of relevant studies. Methods: We systematically searched several databases, including PubMed, EMBASE and Web of Science for articles pertaining to the relationship between pretreatment serum CA 19–9 levels and prognosis in patients with colorectal cancer (CRC). The reported hazard ratios (HR) of overall survival (OS), disease-free survival (DFS), pooled progression-free survival (PFS) and recurrence-free survival (RFS) in the analyzed studies were compared by fixed effects/random effects models. Results: Seventeen studies involving 6434 patients with CRC were included in our meta-analysis. A comprehensive analysis of the collected data revealed that high serum CA 19–9 levels before treatment were significantly associated with poor OS (HR: 1.58, 95% CI: 1.36–1.83, P

Suggested Citation

  • Zhan Yu & Zhen Chen & Jian Wu & Zhong Li & Yugang Wu, 2017. "Prognostic value of pretreatment serum carbohydrate antigen 19-9 level in patients with colorectal cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-12, November.
    • Handle: RePEc:plo:pone00:0188139
    DOI: 10.1371/journal.pone.0188139
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