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Decreased prevalence of cancer in patients with multiple sclerosis: A case-control study

Author

Listed:
  • Xavier Moisset
  • Maud Perié
  • Bruno Pereira
  • Emilie Dumont
  • Christine Lebrun-Frenay
  • François-Xavier Lesage
  • Frederic Dutheil
  • Frederic Taithe
  • Pierre Clavelou

Abstract

Background: Studies of cancer prevalence have produced conflicting results concerning the relative risk of overall and specific sub-types of cancer in patients with multiple sclerosis (MS). Contemporary controls and information on tobacco use and alcohol consumption are generally missing from previous studies. Objectives: To evaluate lifetime cancer prevalence in a large cohort of MS patients relative to appropriate controls. Methods: We conducted a case-control study, using a postal survey of a cohort of MS patients. Of the 1574 questionnaires sent, 1107 could be used for statistical analysis. Data from 1568 controls were prospectively collected using the same self-administered survey among consecutive out-patients in a single neurology department. Propensity scores matched on age, gender, and history of smoking and alcohol consumption were calculated. Results: Among the MS patients, 7.32% had ever presented with a cancer, whereas 12,63% of the controls had, leading to a bootstrap matched odds ratio (OR) of 0.63; 95% CI 0.57–0.70. Although only exploratory, the use of DMT (immunomodulators or immunosupressants) did not appear to increase this risk (p = 0.42). The disease course also did not affect cancer prevalence. Conclusion: MS was associated with a reduced overall cancer risk.

Suggested Citation

  • Xavier Moisset & Maud Perié & Bruno Pereira & Emilie Dumont & Christine Lebrun-Frenay & François-Xavier Lesage & Frederic Dutheil & Frederic Taithe & Pierre Clavelou, 2017. "Decreased prevalence of cancer in patients with multiple sclerosis: A case-control study," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0188120
    DOI: 10.1371/journal.pone.0188120
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    References listed on IDEAS

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    1. Peter C. Austin, 2009. "The Relative Ability of Different Propensity Score Methods to Balance Measured Covariates Between Treated and Untreated Subjects in Observational Studies," Medical Decision Making, , vol. 29(6), pages 661-677, November.
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