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Clinicopathological and prognostic value of transforming acidic coiled-coil-containing protein 3 (TACC3) expression in soft tissue sarcomas

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Listed:
  • Kotaro Matsuda
  • Hiroaki Miyoshi
  • Koji Hiraoka
  • Shintaro Yokoyama
  • Toshiaki Haraguchi
  • Toshihiro Hashiguchi
  • Tetsuya Hamada
  • Naoto Shiba
  • Koichi Ohshima

Abstract

Transforming acidic coiled-coil-containing protein 3 (TACC3), a microtubule regulator, is associated with various cancers. However, the relationship between TACC3 and soft tissue sarcomas (STS) remains unclear. We investigated the expression of TACC3 in 136 STS patient samples using immunohistochemical (IHC) staining, and the statistical associations between TACC3 expression and clinicopathological characteristics were evaluated. Additionally, the expression levels of the tumor suppressor p53 and of the cell proliferation marker Ki-67 were also assessed by IHC. High TACC3 expression was detected in 94/136 of STS cases (69.1%), and significantly correlated with higher grade according to the French Fédération Nationale des Centres de Lutte Contre le Cancer system (P

Suggested Citation

  • Kotaro Matsuda & Hiroaki Miyoshi & Koji Hiraoka & Shintaro Yokoyama & Toshiaki Haraguchi & Toshihiro Hashiguchi & Tetsuya Hamada & Naoto Shiba & Koichi Ohshima, 2017. "Clinicopathological and prognostic value of transforming acidic coiled-coil-containing protein 3 (TACC3) expression in soft tissue sarcomas," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-14, November.
    • Handle: RePEc:plo:pone00:0188096
    DOI: 10.1371/journal.pone.0188096
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