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Elevated N-telopeptide as a potential diagnostic marker for bone metastasis in lung cancer: A meta-analysis

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  • Boxuan Liu
  • Yun Zhao
  • Jingyan Yuan
  • Lizhong Zeng
  • Ruiying Sun
  • Xia Meng
  • Shuanying Yang

Abstract

Background: Growing evidence indicates that the cross-linked N-telopeptide of type I collagen (NTx) is likely to be involved in the development of bone metastasis among lung cancer patients. We perform a meta-analysis to disclose the correlation between bone metastasis and NTx and also to evaluate its value in diagnosis of bone metastasis (BM) in lung cancer. Method: Electronic databases were searched and calculated the weighted mean difference (WMD) with 95% confidence interval (CI) to assess the expression difference of NTx between BM+ and BM- lung cancer patients. Moreover, we conducted a sensitivity and specificity test and drew a summary receiver operating characteristic curve (SROC) to assess the diagnostic value of NTx in discerning bone metastasis. Results: A total of eleven studies with 1108 individuals were included in this analysis. The results showed an increased NTx was correlated with the incidence of lung cancer (P

Suggested Citation

  • Boxuan Liu & Yun Zhao & Jingyan Yuan & Lizhong Zeng & Ruiying Sun & Xia Meng & Shuanying Yang, 2017. "Elevated N-telopeptide as a potential diagnostic marker for bone metastasis in lung cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-12, November.
    • Handle: RePEc:plo:pone00:0187860
    DOI: 10.1371/journal.pone.0187860
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