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Aldehyde dehydrogenase 1 isoenzyme expression as a marker of cancer stem cells correlates to histopathological features in head and neck cancer: A meta-analysis

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  • Yue Dong
  • Sebastian Ochsenreither
  • Chengxuan Cai
  • Andreas M Kaufmann
  • Andreas E Albers
  • Xu Qian

Abstract

There is a lack of predictive biomarkers that can identify patients with head and neck squamous cell carcinoma (HNSCC) who will experience treatment failure and develop drug resistance, recurrence, and metastases. Cancer stem-like cells (CSC) were identified as a subset of cells within the tumor in a variety of solid tumors including HNSCC. CSC are considered the tumor-initiating population responsible for recurrence or metastasis and are associated with therapy resistance. This meta-analysis including fourteen studies with altogether 1258 patients updates and summarizes all relevant data on the impact of ALDH1+ CSC on the prognosis of HNSCC and its association with clinicopathological parameters. ALDH1 expression is highly correlated with tumor differentiation (G3 vs. G1+G2; odds ratio = 2.85. 95% CI: 1.72–4.73, P

Suggested Citation

  • Yue Dong & Sebastian Ochsenreither & Chengxuan Cai & Andreas M Kaufmann & Andreas E Albers & Xu Qian, 2017. "Aldehyde dehydrogenase 1 isoenzyme expression as a marker of cancer stem cells correlates to histopathological features in head and neck cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0187615
    DOI: 10.1371/journal.pone.0187615
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