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Evaluating the glucose raising effect of established loci via a genetic risk score

Author

Listed:
  • Eirini Marouli
  • Stavroula Kanoni
  • Vasiliki Mamakou
  • Sophie Hackinger
  • Lorraine Southam
  • Bram Prins
  • Angela Rentari
  • Maria Dimitriou
  • Eleni Zengini
  • Fragiskos Gonidakis
  • Genovefa Kolovou
  • Vassilis Kontaxakis
  • Loukianos Rallidis
  • Nikolaos Tentolouris
  • Anastasia Thanopoulou
  • Klea Lamnissou
  • George Dedoussis
  • Eleftheria Zeggini
  • Panagiotis Deloukas

Abstract

Recent genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with glucose levels. We tested the hypothesis here whether the cumulative effect of glucose raising SNPs, assessed via a score, is associated with glucose levels. A total of 1,434 participants of Greek descent from the THISEAS study and 1,160 participants form the GOMAP study were included in this analysis. We developed a genetic risk score (GRS), based on the known glucose-raising loci, in order to investigate the cumulative effect of known glucose loci on glucose levels. In the THISEAS study, the GRS score was significantly associated with increased glucose levels (mmol/L) (β ± SE: 0.024 ± 0.004, P = 8.27e-07). The effect of the genetic risk score was also significant in the GOMAP study (β ± SE: 0.011 ± 0.005, P = 0.031). In the meta-analysis of the two studies both scores were significantly associated with higher glucose levels GRS: β ± SE: 0.019 ± 0.003, P = 1.41e-09. Also, variants at the SLC30A8, PROX1, MTNR1B, ADRA2A, G6PC2, LPIN3 loci indicated nominal evidence for association with glucose levels (p

Suggested Citation

  • Eirini Marouli & Stavroula Kanoni & Vasiliki Mamakou & Sophie Hackinger & Lorraine Southam & Bram Prins & Angela Rentari & Maria Dimitriou & Eleni Zengini & Fragiskos Gonidakis & Genovefa Kolovou & Va, 2017. "Evaluating the glucose raising effect of established loci via a genetic risk score," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0186669
    DOI: 10.1371/journal.pone.0186669
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