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Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials

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  • Helene M Wolsk
  • Bo L Chawes
  • Augusto A Litonjua
  • Bruce W Hollis
  • Johannes Waage
  • Jakob Stokholm
  • Klaus Bønnelykke
  • Hans Bisgaard
  • Scott T Weiss

Abstract

Background: We recently published two independent randomized controlled trials of vitamin D supplementation during pregnancy, both indicating a >20% reduced risk of asthma/recurrent wheeze in the offspring by 3 years of age. However, neither reached statistical significance. Objective: To perform a combined analysis of the two trials and investigate whether maternal 25-hydroxy-vitamin D (25(OH)D) level at trial entry modified the intervention effect. Methods: VDAART (N = 806) and COPSAC2010. (N = 581) randomized pregnant women to daily high-dose vitamin D3 (4,000 IU/d and 2,400 IU/d, respectively) or placebo. All women also received a prenatal vitamin containing 400 IU/d vitamin D3. The primary outcome was asthma/recurrent wheeze from 0-3yrs. Secondary end-points were specific IgE, total IgE, eczema and lower respiratory tract infections (LRTI). We conducted random effects combined analyses of the treatment effect, individual patient data (IPD) meta-analyses, and analyses stratified by 25(OH)D level at study entry. Results: The analysis showed a 25% reduced risk of asthma/recurrent wheeze at 0-3yrs: adjusted odds ratio (aOR) = 0.74 (95% CI, 0.57–0.96), p = 0.02. The effect was strongest among women with 25(OH)D level ≥30ng/ml at study entry: aOR = 0.54 (0.33–0.88), p = 0.01, whereas no significant effect was observed among women with 25(OH)D level

Suggested Citation

  • Helene M Wolsk & Bo L Chawes & Augusto A Litonjua & Bruce W Hollis & Johannes Waage & Jakob Stokholm & Klaus Bønnelykke & Hans Bisgaard & Scott T Weiss, 2017. "Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0186657
    DOI: 10.1371/journal.pone.0186657
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    Cited by:

    1. Stefan Pilz & Armin Zittermann & Rima Obeid & Andreas Hahn & Pawel Pludowski & Christian Trummer & Elisabeth Lerchbaum & Faustino R. Pérez-López & Spyridon N. Karras & Winfried März, 2018. "The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data," IJERPH, MDPI, vol. 15(10), pages 1-19, October.

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