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The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients

Author

Listed:
  • Xiao-fei Wang
  • Yi-tong Zhu
  • Jia-jia Wang
  • Da-xiong Zeng
  • Chuan-yong Mu
  • Yan-bin Chen
  • Wei Lei
  • Ye-han Zhu
  • Jian-an Huang

Abstract

Background: Interleukin-17 (IL-17) plays an important role in cancer progression. Previous studies remained controversial regarding the correlation between IL-17 expression and lung cancer (LC) prognosis. To comprehensively and quantitatively summarize the prognostic value of IL-17 expression in LC patients, a systematic review and meta-analysis were performed. Methods: We identified the relevant literatures by searching the PubMed, EMBASE, Cochrane Library, SinoMed, China National Knowledge Infrastructure (CNKI) and Wanfang Data databases, up until April 1, 2017. Overall survival (OS), disease free survival (DFS) and clinicopathological characteristics were collected from relevant studies. Pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI) were calculated to estimate the effective value of IL-17 expression on clinical outcomes. Results: Six studies containing 479 Chinese LC patients were involved in this meta-analysis. The results indicated high IL-17 expression was independently correlated with poorer OS (HR = 1.82, 95% CI 1.44–2.29, P

Suggested Citation

  • Xiao-fei Wang & Yi-tong Zhu & Jia-jia Wang & Da-xiong Zeng & Chuan-yong Mu & Yan-bin Chen & Wei Lei & Ye-han Zhu & Jian-an Huang, 2017. "The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0185168
    DOI: 10.1371/journal.pone.0185168
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