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Trends in prevalence of multi drug resistant tuberculosis in sub-Saharan Africa: A systematic review and meta-analysis

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  • Baba Maiyaki Musa
  • Aishatu L Adamu
  • Najibah A Galadanci
  • Bashir Zubayr
  • Chisom N Odoh
  • Muktar H Aliyu

Abstract

Background: Multidrug resistant tuberculosis (MDR-TB), is an emerging public health problem in sub-Saharan Africa (SSA). This study aims to determine the trends in prevalence of MDR-TB among new TB cases in sub-Saharan Africa over two decades. Methods: We searched electronic data bases and accessed all prevalence studies of MDR-TB within SSA between 2007 and 2017. We determined pooled prevalence estimates using random effects models and determined trends using meta-regression. Results: Results: We identified 915 studies satisfying inclusion criteria. Cumulatively, studies reported on MDR-TB culture of 34,652 persons. The pooled prevalence of MDR-TB in new cases was 2.1% (95% CI; 1.7–2.5%). There was a non-significant decline in prevalence by 0.12% per year. Conclusion: We found a low prevalence estimate of MDR-TB, and a slight temporal decline over the study period. There is a need for continuous MDR-TB surveillance among patients with TB.

Suggested Citation

  • Baba Maiyaki Musa & Aishatu L Adamu & Najibah A Galadanci & Bashir Zubayr & Chisom N Odoh & Muktar H Aliyu, 2017. "Trends in prevalence of multi drug resistant tuberculosis in sub-Saharan Africa: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-15, September.
    • Handle: RePEc:plo:pone00:0185105
    DOI: 10.1371/journal.pone.0185105
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