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Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016

Author

Listed:
  • Magdalena Rosińska
  • Natalia Parda
  • Agnieszka Kołakowska
  • Paulina Godzik
  • Karolina Zakrzewska
  • Kazimierz Madaliński
  • Andrzej Zieliński
  • Anna Boguradzka
  • Rafał Gierczyński
  • Małgorzata Stępień

Abstract

Background & aims: There is a considerable burden of hepatitis C in Europe related to the lack of prompt diagnosis. We aimed to estimate the prevalence and related risk factors of HCV infections by the stages of liver fibrosis, using non-invasive methods, to understand testing needs in Poland. Methods: A cross-sectional study was conducted in 2012–2016 adopting a stratified random sampling of primary health care units followed by systematic sampling of patients within each unit. Study participants filled a questionnaire and donated blood for laboratory HCV testing. Additionally, the results of liver function tests and platelet count were collected to calculate APRI and FIB-4 scores. Cases were classified according to the level of fibrosis: ‘significant fibrosis’ (APRI≥0.7 or FIB4≥1.45) and ‘no significant fibrosis’ (APRI

Suggested Citation

  • Magdalena Rosińska & Natalia Parda & Agnieszka Kołakowska & Paulina Godzik & Karolina Zakrzewska & Kazimierz Madaliński & Andrzej Zieliński & Anna Boguradzka & Rafał Gierczyński & Małgorzata Stępień, 2017. "Factors associated with hepatitis C prevalence differ by the stage of liver fibrosis: A cross-sectional study in the general population in Poland, 2012-2016," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0185055
    DOI: 10.1371/journal.pone.0185055
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