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Sociodemographic correlates of HIV drug resistance and access to drug resistance testing in British Columbia, Canada

Author

Listed:
  • Genevieve Rocheleau
  • Conrado Franco-Villalobos
  • Natalia Oliveira
  • Zabrina L Brumme
  • Melanie Rusch
  • Jeannie Shoveller
  • Chanson J Brumme
  • P Richard Harrigan

Abstract

Sociodemographic correlates of engagement in human immunodeficiency virus (HIV) care are well studied, however the association with accessing drug resistance testing (DRT) and the development of drug resistance have not been characterized. Between 1996–2014, 11 801 HIV patients accessing therapy in British Columbia were observed longitudinally. A subset of 9456 patients had testable viral load; of these 8398 were linked to census data. Sociodemographic (census tract-level) and clinical (individual-level) correlates of DRT were assessed using multivariable General Estimating Equation logistic regression adjusted odds ratios (aOR). The mean number of tests per patient was 2.1 (Q1-Q3; 0–3). Separately, any drug resistance was determined using IAS-USA (2013) list for 5703 initially treatment naïve patients without baseline resistance; 5175 were census-linked (mean of 1.5 protease-reverse transcriptase sequences/patient, Q1-Q3; 0–2). Correlates of detecting drug resistance in this subset were analyzed using Cox PH regression adjusted hazard ratios (aHR). Our results indicate baseline CD4

Suggested Citation

  • Genevieve Rocheleau & Conrado Franco-Villalobos & Natalia Oliveira & Zabrina L Brumme & Melanie Rusch & Jeannie Shoveller & Chanson J Brumme & P Richard Harrigan, 2017. "Sociodemographic correlates of HIV drug resistance and access to drug resistance testing in British Columbia, Canada," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-15, September.
    • Handle: RePEc:plo:pone00:0184848
    DOI: 10.1371/journal.pone.0184848
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    1. Jan P Vandenbroucke & Erik von Elm & Douglas G Altman & Peter C Gøtzsche & Cynthia D Mulrow & Stuart J Pocock & Charles Poole & James J Schlesselman & Matthias Egger & for the STROBE Initiative, 2007. "Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 4(10), pages 1-27, October.
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