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Risk of pneumonia in patients with gastroesophageal reflux disease: A population-based cohort study

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  • Wan-Tseng Hsu
  • Chih-Cheng Lai
  • Ya-Hui Wang
  • Ping-Huei Tseng
  • Kun Wang
  • Cheng-Yi Wang
  • Likwang Chen

Abstract

Purpose: The prevalence of gastroesophagel reflux disease (GERD) has steadily increased. However, the association between GERD itself and the risk of pneumonia remains unclear. This study aimed to investigate the association between GERD and long-term risk of pneumonia and to identify the major risk factors for pneumonia in GERD patients. Methods: Using the Taiwan National Health Insurance Research Database, we identified patients who were newly diagnosed with GERD and treated with proton pump inhibitors (PPIs) from January 1, 2004 through December 31, 2010. Two groups comprising 15,715 GERD cases and 15,715 non-GERD matched controls were generated using propensity score matching, thereby making the differences in basic demographics, concomitant medication use, and comorbidities between the two groups inconsiderable. Results: Cumulative incidence of pneumonia was significantly higher in the patients with GERD than that in the non-GERD matched controls, with an adjusted HR of 1.48 (95% confidence interval [CI] = 1.31–1.67; P

Suggested Citation

  • Wan-Tseng Hsu & Chih-Cheng Lai & Ya-Hui Wang & Ping-Huei Tseng & Kun Wang & Cheng-Yi Wang & Likwang Chen, 2017. "Risk of pneumonia in patients with gastroesophageal reflux disease: A population-based cohort study," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0183808
    DOI: 10.1371/journal.pone.0183808
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