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Relationship between response to aripiprazole once-monthly and paliperidone palmitate on work readiness and functioning in schizophrenia: A post-hoc analysis of the QUALIFY study

Author

Listed:
  • Steven G Potkin
  • Jean-Yves Loze
  • Carlos Forray
  • Ross A Baker
  • Christophe Sapin
  • Timothy Peters-Strickland
  • Maud Beillat
  • Anna-Greta Nylander
  • Peter Hertel
  • Simon Nitschky Schmidt
  • Anders Ettrup
  • Anna Eramo
  • Karina Hansen
  • Dieter Naber

Abstract

Schizophrenia is a chronic disease with negative impact on patients’ employment status and quality of life. This post-hoc analysis uses data from the QUALIFY study to elucidate the relationship between work readiness and health-related quality of life and functioning. QUALIFY was a 28-week, randomized study (NCT01795547) comparing the treatment effectiveness of aripiprazole once-monthly 400 mg and paliperidone palmitate once-monthly using the Heinrichs-Carpenter Quality-of-Life Scale as the primary endpoint. Also, patients’ capacity to work and work readiness (Yes/No) was assessed with the Work Readiness Questionnaire. We categorized patients, irrespective of treatment, by work readiness at baseline and week 28: No to Yes (n = 41), Yes to Yes (n = 49), or No at week 28 (n = 118). Quality-of-Life Scale total, domains, and item scores were assessed with a mixed model of repeated measures. Patients who shifted from No to Yes in work readiness showed robust improvements on Quality-of-Life Scale total scores, significantly greater than patients not ready to work at week 28 (least squares mean difference: 11.6±2.6, p

Suggested Citation

  • Steven G Potkin & Jean-Yves Loze & Carlos Forray & Ross A Baker & Christophe Sapin & Timothy Peters-Strickland & Maud Beillat & Anna-Greta Nylander & Peter Hertel & Simon Nitschky Schmidt & Anders Ett, 2017. "Relationship between response to aripiprazole once-monthly and paliperidone palmitate on work readiness and functioning in schizophrenia: A post-hoc analysis of the QUALIFY study," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0183475
    DOI: 10.1371/journal.pone.0183475
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