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A novel noninvasive surface ECG analysis using interlead QRS dispersion in arrhythmogenic right ventricular cardiomyopathy

Author

Listed:
  • Wan-Hsin Hsieh
  • Chin-Yu Lin
  • Abigail Louise D Te
  • Men-Tzung Lo
  • Cheng-I Wu
  • Fa-Po Chung
  • Yi-Chung Chang
  • Shih-Lin Chang
  • Chen Lin
  • Li-Wei Lo
  • Yu-Feng Hu
  • Jo-Nan Liao
  • Yun-Yu Chen
  • Shih-Jie Jhuo
  • Sunu Budhi Raharjo
  • Yenn-Jiang Lin
  • Shih-Ann Chen

Abstract

Background: This study investigated the feasibility of using the precordial surface ECG lead interlead QRS dispersion (IQRSD) in the identification of abnormal ventricular substrate in arrhythmogenic right ventricular cardiomyopathy (ARVC). Methods: Seventy-one consecutive patients were enrolled and reclassified into 4 groups: definite ARVC with epicardial ablation (Group 1), ARVC with ventricular tachycardia (VT, Group 2), idiopathic right ventricular outflow tract VT without ARVC (Group 3), and controls without VT (Group 4). IQRSD was quantified by the angular difference between the reconstruction vectors obtained from the QRS-loop decomposition, based on a principal component analysis (PCA). Electroanatomic mapping and simulated ECGs were used to investigate the relationship between QRS dispersion and abnormal substrate. Results: The percentage of the QRS loop area in the Group 1–2 was smaller than the controls (P = 0.01). The IQRSD between V1-V2 could differentiate all VTs from control (P

Suggested Citation

  • Wan-Hsin Hsieh & Chin-Yu Lin & Abigail Louise D Te & Men-Tzung Lo & Cheng-I Wu & Fa-Po Chung & Yi-Chung Chang & Shih-Lin Chang & Chen Lin & Li-Wei Lo & Yu-Feng Hu & Jo-Nan Liao & Yun-Yu Chen & Shih-Ji, 2017. "A novel noninvasive surface ECG analysis using interlead QRS dispersion in arrhythmogenic right ventricular cardiomyopathy," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-18, August.
    • Handle: RePEc:plo:pone00:0182364
    DOI: 10.1371/journal.pone.0182364
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