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The risk of new-onset diabetes in antidepressant users – A systematic review and meta-analysis

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  • Virginio Salvi
  • Ilaria Grua
  • Giancarlo Cerveri
  • Claudio Mencacci
  • Francesco Barone-Adesi

Abstract

Background: Antidepressant Drugs (ADs) are among the most commonly prescribed medications in developed countries. The available epidemiological evidence suggests an association between AD use and higher risk of developing type 2 diabetes mellitus. However, some methodological issues make the interpretation of these results difficult. Moreover, very recent studies provided conflicting results. Given the high prevalence of both diabetes and AD use in many countries, clarifying whether this association is causal is of extreme relevance for the public health. The aim of the present study is to provide an up-to-date evaluation of the evidence in support of a causal role of ADs in inducing diabetes. Methods and findings: A systematic literature search was conducted to identify relevant studies in MEDLINE (PubMed), PsycINFO, and International Pharmaceutical Abstracts (IPA) through 31st December 2016. Only studies assessing the incidence of new-onset diabetes in subjects treated with ADs were included. Results were pooled using a random-effects meta-analysis. Moreover, we extensively reviewed the role of the different sources of bias that have been proposed to explain the association between AD and diabetes. Twenty studies met the inclusion criteria. In the meta-analysis, the association between AD use and diabetes was still evident after the inclusion of the recent negative studies [pooled relative risk = 1.27, 95% confidence interval (CI), 1.19–1.35; p

Suggested Citation

  • Virginio Salvi & Ilaria Grua & Giancarlo Cerveri & Claudio Mencacci & Francesco Barone-Adesi, 2017. "The risk of new-onset diabetes in antidepressant users – A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0182088
    DOI: 10.1371/journal.pone.0182088
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    References listed on IDEAS

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    1. Francesco Barone-Adesi & Jennifer E Dent & David Dajnak & Sean Beevers & H Ross Anderson & Frank J Kelly & Derek G Cook & Peter H Whincup, 2015. "Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-16, November.
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