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Applying time-frequency analysis to assess cerebral autoregulation during hypercapnia

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Listed:
  • Michał M Placek
  • Paweł Wachel
  • D Robert Iskander
  • Peter Smielewski
  • Agnieszka Uryga
  • Arkadiusz Mielczarek
  • Tomasz A Szczepański
  • Magdalena Kasprowicz

Abstract

Objective: Classic methods for assessing cerebral autoregulation involve a transfer function analysis performed using the Fourier transform to quantify relationship between fluctuations in arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV). This approach usually assumes the signals and the system to be stationary. Such an presumption is restrictive and may lead to unreliable results. The aim of this study is to present an alternative method that accounts for intrinsic non-stationarity of cerebral autoregulation and the signals used for its assessment. Methods: Continuous recording of CBFV, ABP, ECG, and end-tidal CO2 were performed in 50 young volunteers during normocapnia and hypercapnia. Hypercapnia served as a surrogate of the cerebral autoregulation impairment. Fluctuations in ABP, CBFV, and phase shift between them were tested for stationarity using sphericity based test. The Zhao-Atlas-Marks distribution was utilized to estimate the time—frequency coherence (TFCoh) and phase shift (TFPS) between ABP and CBFV in three frequency ranges: 0.02–0.07 Hz (VLF), 0.07–0.20 Hz (LF), and 0.20–0.35 Hz (HF). TFPS was estimated in regions locally validated by statistically justified value of TFCoh. The comparison of TFPS with spectral phase shift determined using transfer function approach was performed. Results: The hypothesis of stationarity for ABP and CBFV fluctuations and the phase shift was rejected. Reduced TFPS was associated with hypercapnia in the VLF and the LF but not in the HF. Spectral phase shift was also decreased during hypercapnia in the VLF and the LF but increased in the HF. Time-frequency method led to lower dispersion of phase estimates than the spectral method, mainly during normocapnia in the VLF and the LF. Conclusion: The time—frequency method performed no worse than the classic one and yet may offer benefits from lower dispersion of phase shift as well as a more in-depth insight into the dynamic nature of cerebral autoregulation.

Suggested Citation

  • Michał M Placek & Paweł Wachel & D Robert Iskander & Peter Smielewski & Agnieszka Uryga & Arkadiusz Mielczarek & Tomasz A Szczepański & Magdalena Kasprowicz, 2017. "Applying time-frequency analysis to assess cerebral autoregulation during hypercapnia," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-23, July.
    • Handle: RePEc:plo:pone00:0181851
    DOI: 10.1371/journal.pone.0181851
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    1. Xiping Gong & Jia Liu & Pei Dong & Pandeng Zhang & Na Li & Xingquan Zhao & Yongjun Wang, 2013. "Assessment of Dynamic Cerebral Autoregulation in Patients with Basilar Artery Stenosis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
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