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Anti-citrullinated protein antibody positive rheumatoid arthritis is primarily determined by rheumatoid factor titre and the shared epitope rather than smoking per se

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  • Dan Murphy
  • Derek Mattey
  • David Hutchinson

Abstract

Objective: To analyse the relationship between rheumatoid factor (RF) titre, smoking and HLA-DRB1 alleles coding a “shared epitope” (SE) in relation to anti-citrullinated protein antibody (ACPA) positivity in rheumatoid arthritis (RA). Methods: RA patients (n = 658) attending rheumatology clinics in Cornwall, UK (cohort 1) were stratified according to RF and ACPA titre, and smoking pack years at diagnosis. A further 409 RA patients from North Staffordshire, UK (cohort 2) were studied to confirm the relationship between RF levels, smoking and ACPA positivity in relation to SE status. Results: In cohort 1 there was a trend (p 20 pack years conferred an increased risk of anti-CCP positive RA (158/200 (79%)), compared to having never smoked (146/235 (62%), p =

Suggested Citation

  • Dan Murphy & Derek Mattey & David Hutchinson, 2017. "Anti-citrullinated protein antibody positive rheumatoid arthritis is primarily determined by rheumatoid factor titre and the shared epitope rather than smoking per se," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-11, July.
    • Handle: RePEc:plo:pone00:0180655
    DOI: 10.1371/journal.pone.0180655
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