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Maternal 25(OH)D concentrations ≥40 ng/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center

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Listed:
  • Sharon L McDonnell
  • Keith A Baggerly
  • Carole A Baggerly
  • Jennifer L Aliano
  • Christine B French
  • Leo L Baggerly
  • Myla D Ebeling
  • Charles S Rittenberg
  • Christopher G Goodier
  • Julio F Mateus Niño
  • Rebecca J Wineland
  • Roger B Newman
  • Bruce W Hollis
  • Carol L Wagner

Abstract

Background: Given the high rate of preterm birth (PTB) nationwide and data from RCTs demonstrating risk reduction with vitamin D supplementation, the Medical University of South Carolina (MUSC) implemented a new standard of care for pregnant women to receive vitamin D testing and supplementation. Objectives: To determine if the reported inverse relationship between maternal 25(OH)D and PTB risk could be replicated at MUSC, an urban medical center treating a large, diverse population. Methods: Medical record data were obtained for pregnant patients aged 18–45 years between September 2015 and December 2016. During this time, a protocol that included 25(OH)D testing at first prenatal visit with recommended follow-up testing was initiated. Free vitamin D supplements were offered and the treatment goal was ≥40 ng/mL. PTB rates (

Suggested Citation

  • Sharon L McDonnell & Keith A Baggerly & Carole A Baggerly & Jennifer L Aliano & Christine B French & Leo L Baggerly & Myla D Ebeling & Charles S Rittenberg & Christopher G Goodier & Julio F Mateus Niñ, 2017. "Maternal 25(OH)D concentrations ≥40 ng/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0180483
    DOI: 10.1371/journal.pone.0180483
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