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Prognostic significance of microRNA-101 in solid tumor: A meta-analysis

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  • Xianxiong Ma
  • Jie Bai
  • Gengchen Xie
  • Yulin Liu
  • Xiaoming Shuai
  • Kaixiong Tao

Abstract

MicroRNA-101 has been reported as an important factor in carcinogenesis of several malignant tumors. However, its actual role in prognosis among solid malignancies remains unclear. Accordingly, we performed this meta-analysis aiming to identify prognostic significance of miR-101 in solid tumor. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) or disease-free survival (DFS)/metastasis-free survival (MFS)/progression-free survival (PFS)/relapse-free survival (RFS)/time-to progression (TTP) were estimated with random effects or fixed effects models on the basis of heterogeneity. Subgroup analysis, sensitive analysis and meta-regression analysis were also conducted to clarify the possible confounding factors and investigate the source of heterogeneity. Publication bias was evaluated by using Begg’s and Egger’s tests. A total of 21 studies containing 3753 cases were selected into our quantitative analysis via electronic database search. A lower expression of miR-101 was significantly associated with worse OS (HR = 0.66, 95%CI [0.52–0.85], P = 0.001) and PFS (HR = 0.70, 95%CI [0.51–0.95], P = 0.023) in patients with solid tumor. The under-expression of miRNA-101 is a credible indicator of poorer prognosis in several of solid malignancies.

Suggested Citation

  • Xianxiong Ma & Jie Bai & Gengchen Xie & Yulin Liu & Xiaoming Shuai & Kaixiong Tao, 2017. "Prognostic significance of microRNA-101 in solid tumor: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-16, July.
    • Handle: RePEc:plo:pone00:0180173
    DOI: 10.1371/journal.pone.0180173
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