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The characteristics of screening and confirmatory test results for HIV in Xi’an, China

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  • Linchuan Wang
  • Kai-Hua Zhou
  • He-Ping Zhao
  • Ji-Han Wang
  • Hai-Chao Zheng
  • Yan Yu
  • Wei Chen

Abstract

Objectives: Individuals with recent or acute HIV infection are more infectious than those with established infection. Our objective was to analyze the characteristics of detection among HIV infections in Xi'an. Methods: A 4th-generation kit (Architect HIV Ag/Ab Combo) and three 3rd-generationEIA kits (WanTai, XinChuang and Livzon) were used for HIV screening. Overall, 665 individuals were identified as positive and were tested by western blotting (WB). The characteristics of the screening and confirmatory tests were analyzed, including the band patterns, the early detection performance and the false-positive rates. Results: In total, 561 of the 665 patients were confirmed as having HIV-1 infection, and no HIV-2 specific band was observed. Among these 561 WB-positive cases, reactivity to greater than or equal to 9 antigens was the most commonly observed pattern (83.18%), and the absence of reactivity to p17, p31 and gp41 was detected in 6.44%, 5.9% and 2.86% of the cases, respectively. Two cases were positive by the 4th-generation assay but negative by the 3rd-generation assay for HIV screening and had seroconversion. The false-positive rate of the Architect HIV Ag/Ab Combo (22.01%) was significantly higher than those of WanTai (9.88%), XinChuang (10.87%) and Livzon (8.93%), p

Suggested Citation

  • Linchuan Wang & Kai-Hua Zhou & He-Ping Zhao & Ji-Han Wang & Hai-Chao Zheng & Yan Yu & Wei Chen, 2017. "The characteristics of screening and confirmatory test results for HIV in Xi’an, China," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0180071
    DOI: 10.1371/journal.pone.0180071
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