IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0179895.html
   My bibliography  Save this article

Microstructural integrity of white matter tracts amongst older fallers: A DTI study

Author

Listed:
  • Yoke Queen Wong
  • Li Kuo Tan
  • Pohchoo Seow
  • Maw Pin Tan
  • Khairul Azmi Abd Kadir
  • Anushya Vijayananthan
  • Norlisah Ramli

Abstract

Objectives: This study assesses the whole brain microstructural integrity of white matter tracts (WMT) among older individuals with a history of falls compared to non-fallers. Methods: 85 participants (43 fallers, 42 non-fallers) were evaluated with conventional MRI and diffusion tensor imaging (DTI) sequences of the brain. DTI metrics were obtained from selected WMT using tract-based spatial statistics (TBSS) method. This was followed by binary logistic regression to investigate the clinical variables that could act as confounding elements on the outcomes. The TBSS analysis was then repeated, but this time including all significant predictor variables from the regression analysis as TBSS covariates. Results: The mean diffusivity (MD) and axial diffusivity (AD) and to a lesser extent radial diffusivity (RD) values of the projection fibers and commissural bundles were significantly different in fallers (p

Suggested Citation

  • Yoke Queen Wong & Li Kuo Tan & Pohchoo Seow & Maw Pin Tan & Khairul Azmi Abd Kadir & Anushya Vijayananthan & Norlisah Ramli, 2017. "Microstructural integrity of white matter tracts amongst older fallers: A DTI study," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0179895
    DOI: 10.1371/journal.pone.0179895
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179895
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0179895&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0179895?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0179895. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.