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Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis

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  • Anna M Schotthoefer
  • Steven J Schrodi
  • Jennifer K Meece
  • Thomas R Fritsche
  • Sanjay K Shukla

Abstract

Human anaplasmosis (HA) is an emerging tick-borne disease that may present as a mild flu-like illness or a life threatening, sepsis-like condition. Although disease severity is hypothesized to relate to immunopathology and immune dysfunction in humans, studies to directly measure immune responses in infected humans have been very limited. We quantified cytokines in 80 confirmed HA patients using a multiplex chemiluminescence immunoassay system and compared similarly measured responses in 1000 control subjects. Pro-inflammatory cytokines were significantly elevated in HA patients (all seven p

Suggested Citation

  • Anna M Schotthoefer & Steven J Schrodi & Jennifer K Meece & Thomas R Fritsche & Sanjay K Shukla, 2017. "Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-16, June.
    • Handle: RePEc:plo:pone00:0179655
    DOI: 10.1371/journal.pone.0179655
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