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Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population

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  • Giovanny Vinícius Araújo de França
  • Emanuella De Lucia Rolfe
  • Bernardo Lessa Horta
  • Denise Petrucci Gigante
  • John S Yudkin
  • Ken K Ong
  • Cesar Gomes Victora

Abstract

We aimed to identify the independent associations of genomic ancestry and education level with abdominal fat distributions in the 1982 Pelotas birth cohort study, Brazil. In 2,890 participants (1,409 men and 1,481 women), genomic ancestry was assessed using genotype data on 370,539 genome-wide variants to quantify ancestral proportions in each individual. Years of completed education was used to indicate socio-economic position. Visceral fat depth and subcutaneous abdominal fat thickness were measured by ultrasound at age 29–31y; these measures were adjusted for BMI to indicate abdominal fat distributions. Linear regression models were performed, separately by sex. Admixture was observed between European (median proportion 85.3), African (6.6), and Native American (6.3) ancestries, with a strong inverse correlation between the African and European ancestry scores (ρ = -0.93; p

Suggested Citation

  • Giovanny Vinícius Araújo de França & Emanuella De Lucia Rolfe & Bernardo Lessa Horta & Denise Petrucci Gigante & John S Yudkin & Ken K Ong & Cesar Gomes Victora, 2017. "Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-13, June.
    • Handle: RePEc:plo:pone00:0179085
    DOI: 10.1371/journal.pone.0179085
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