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Determinants of generic and specific health-related quality of life in patients with Parkinson’s disease

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  • Xiao-Jing Tu
  • Wen-Juh Hwang
  • Hui-Ing Ma
  • Ling-Hui Chang
  • Shih-Pin Hsu

Abstract

Objectives: Generic and disease-specific health-related quality of life (HRQoL) instruments may reflect different aspects of lives in patients with Parkinson’s disease (PD) and thus be associated with different determinants. We used the same cluster of predictors for the generic and disease-specific HRQoL instruments to examine and compare the determinants of HRQoL. Method: HRQoL was measured in 92 patients with PD by the 36-item Short-Form Health Survey (SF-36) and the 39-item Parkinson’s Disease Questionnaire (PDQ-39). The predictors included demographic and disease characteristics, and motor and non-motor symptoms. Multiple regression analyses were used to identify HRQoL determinants. Results: Depressive symptoms and motor difficulties of daily living were the first two significant determinants for both instruments. The other significant determinant for the SF-36 was fatigue and non-motor difficulties of daily living, and for the PDQ-39 was motor signs of PD. Conclusions: The results suggest the importance of the evaluation and intervention focused on depressive symptoms and motor difficulties of daily living in patients with PD. In addition, the SF-36 seems more related to non-motor symptoms, while the PDQ-39 appears more associated with motor symptoms. This information is important for understanding results from these two instruments and for choosing which to use.

Suggested Citation

  • Xiao-Jing Tu & Wen-Juh Hwang & Hui-Ing Ma & Ling-Hui Chang & Shih-Pin Hsu, 2017. "Determinants of generic and specific health-related quality of life in patients with Parkinson’s disease," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0178896
    DOI: 10.1371/journal.pone.0178896
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    References listed on IDEAS

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    1. Blake J Lawrence & Natalie Gasson & Robert Kane & Romola S Bucks & Andrea M Loftus, 2014. "Activities of Daily Living, Depression, and Quality of Life in Parkinson's Disease," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-5, July.
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    Cited by:

    1. Pablo Martinez-Martin & Guenther Deuschl & Lisa Tonder & Alfons Schnitzler & Jean-Luc Houeto & Lars Timmermann & Joern Rau & Carmen Schade-Brittinger & Valerie Stoker & Marie Vidailhet & Paul Krack & , 2020. "Interpretation of health-related quality of life outcomes in Parkinson’s disease from the EARLYSTIM Study," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-15, August.
    2. Gamze Bayin Donar & Mehmet Top, 2020. "A conceptual framework of quality of life in chronic kidney disease in Turkey: A patient‐focused approach," International Journal of Health Planning and Management, Wiley Blackwell, vol. 35(6), pages 1335-1350, November.
    3. Eduardo Candel-Parra & María Pilar Córcoles-Jiménez & Victoria Delicado-Useros & Marta Carolina Ruiz-Grao & Antonio Hernández-Martínez & Milagros Molina-Alarcón, 2022. "Predictive Model of Quality of Life in Patients with Parkinson’s Disease," IJERPH, MDPI, vol. 19(2), pages 1-13, January.

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