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Interval to vascularization development in cirrhotic precursor nodules in patients with hepatitis B and C virus co-infections

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  • Nai-Chi Chiu
  • Chien-Wei Su
  • Chien-An Liu
  • Yi-Hsiang Huang
  • Yi-You Chiou

Abstract

With the widespread use of gadoxetic acid-enhanced magnetic resonance imaging, liver nodules appearing as hypovascular in the arterial phase and hypointense in the hepatobiliary phase, defined as hypovascular hypointense nodules, are increasingly detected in patients with cirrhosis and are considered precursor nodules. We sought to evaluate the interval to vascularization development in hepatitis C virus/hepatitis B virus co-infected-associated precursor nodules (BC-HHN group) compared with that in hepatitis C virus mono-infected-associated precursor nodules (C-HHN group) in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging. The interval to vascularization development was estimated by the Kaplan-Meier method and compared using the Cox proportional hazards model. The mean intervals to vascularization development in the BC-HHN and C-HHN groups were 272.9±31.1 and 603.8±47.6 days, respectively (p

Suggested Citation

  • Nai-Chi Chiu & Chien-Wei Su & Chien-An Liu & Yi-Hsiang Huang & Yi-You Chiou, 2017. "Interval to vascularization development in cirrhotic precursor nodules in patients with hepatitis B and C virus co-infections," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0178841
    DOI: 10.1371/journal.pone.0178841
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