IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0178823.html
   My bibliography  Save this article

Preoperative serum cystatin-C as a potential biomarker for prognosis of renal cell carcinoma

Author

Listed:
  • Shengjie Guo
  • Yunfei Xue
  • Qiuming He
  • Xiaobo He
  • Kunbin Guo
  • Pei Dong
  • Kai Yao
  • Guangwei Yang
  • Dong Chen
  • Zaishang Li
  • Xiangdong Li
  • Zike Qin
  • Zhuowei Liu
  • Wenjie Cheng
  • Chao Guo
  • Meng Zhang
  • Hui Han
  • Fangjian Zhou

Abstract

Purpose: The prognostic value of serum cystatin-C (Cys-C) in renal cell carcinoma (RCC) remains unknown. The purpose of this study is to explore the prognostic value of Cys-C for RCC patients. Patients and methods: The levels of preoperative Cys-C, creatinine (CRE) and estimated glomerular filtration rate (e-GFR) were retrospectively collected in 325 RCC patients undergoing surgery. The cutoff values of Cys-C, CRE and e-GFR were determined by the standardized Cutoff Finder algorithm. The receiver operating characteristic (ROC) curve and pairwise comparison were performed to compare the three variables. Univariate and multivariate Cox regression analyses were performed to investigate the prognostic value of serum Cys-C in RCC. Results: Based on the analysis of Cutoff Finder algorithm, ROC curve and pairwise comparison, the preoperative Cys-C was superior to CRE and e-GFR as a predictive factor in RCC. Multivariate Cox regression analyses showed that high preoperative Cys-C (>1.09 mg/L) was significantly associated with shorter overall survival (OS) in all RCC patients (hazard ratio [HR], 1.59; P = 0.012), patients at pT1-2 (P

Suggested Citation

  • Shengjie Guo & Yunfei Xue & Qiuming He & Xiaobo He & Kunbin Guo & Pei Dong & Kai Yao & Guangwei Yang & Dong Chen & Zaishang Li & Xiangdong Li & Zike Qin & Zhuowei Liu & Wenjie Cheng & Chao Guo & Meng , 2017. "Preoperative serum cystatin-C as a potential biomarker for prognosis of renal cell carcinoma," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-18, June.
    • Handle: RePEc:plo:pone00:0178823
    DOI: 10.1371/journal.pone.0178823
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178823
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178823&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0178823?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0178823. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.