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Cavum septum pellucidum and first-episode psychosis: A meta-analysis

Author

Listed:
  • Hanwen Liu
  • Ling Li
  • Li Shen
  • Xianliang Wang
  • Yazhu Hou
  • Zhiqiang Zhao
  • Lili Gu
  • Jingyuan Mao

Abstract

Objectives: To investigate the prevalence and changes of cavum septum pellucidum (CSP) in first-episode psychosis (FEP) patients. Methods: Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify eligible studies comparing FEP patients and healthy controls from inception to Feb 29, 2016. Results: Ten cross-sectional studies and three longitudinal studies reported in ten articles met our criteria. Our meta-analysis found no significant differences in the prevalence of either “any CSP” (OR = 1.41; 95% CI 0.90–2.20; p = 0.13; I2 = 52.7%) or “large CSP” (OR = 1.10; 95% CI 0.77–1.58; p = 0.59; I2 = 24.1%) between FEP patients and healthy controls. However, the heterogeneity analysis of the prevalence of “any CSP” suggested bias in outcome reporting. Conclusions: The results based on current evidence suggest it is unclear whether “any CSP” is a risk factor for FEP due to the heterogeneity of the studies. There is insufficient evidence to support that “large CSP” is a possible risk factor for FEP.

Suggested Citation

  • Hanwen Liu & Ling Li & Li Shen & Xianliang Wang & Yazhu Hou & Zhiqiang Zhao & Lili Gu & Jingyuan Mao, 2017. "Cavum septum pellucidum and first-episode psychosis: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-20, May.
    • Handle: RePEc:plo:pone00:0177715
    DOI: 10.1371/journal.pone.0177715
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