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Brackish habitat dictates cultivable Actinobacterial diversity from marine sponges

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  • Gregory A Ellis
  • Chris S Thomas
  • Shaurya Chanana
  • Navid Adnani
  • Emily Szachowicz
  • Doug R Braun
  • Mary Kay Harper
  • Thomas P Wyche
  • Tim S Bugni

Abstract

Bacterial communities associated with marine invertebrates such as sponges and ascidians have demonstrated potential as sources of bio-medically relevant small molecules. Metagenomic analysis has shown that many of these invertebrates harbor populations of Actinobacteria, many of which are cultivable. While some populations within invertebrates are transmitted vertically, others are obtained from the environment. We hypothesized that cultivable diversity from sponges living in brackish mangrove habitats have associations with Actinobacterial populations that differ from those found in clear tropical waters. In this study, we analyzed the cultivable Actinobacterial populations from sponges found in these two distinct habitats with the aim of understanding the secondary metabolite potential. Importantly, we wanted to broadly evaluate the potential differences among these groups to guide future Actinobacterial collection strategies for the purposes of drug discovery.

Suggested Citation

  • Gregory A Ellis & Chris S Thomas & Shaurya Chanana & Navid Adnani & Emily Szachowicz & Doug R Braun & Mary Kay Harper & Thomas P Wyche & Tim S Bugni, 2017. "Brackish habitat dictates cultivable Actinobacterial diversity from marine sponges," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-19, July.
  • Handle: RePEc:plo:pone00:0176968
    DOI: 10.1371/journal.pone.0176968
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    References listed on IDEAS

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    1. Utpal Bose & Amitha K Hewavitharana & Miranda E Vidgen & Yi Kai Ng & P Nicholas Shaw & John A Fuerst & Mark P Hodson, 2014. "Discovering the Recondite Secondary Metabolome Spectrum of Salinispora Species: A Study of Inter-Species Diversity," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-10, March.
    2. Torsten Thomas & Lucas Moitinho-Silva & Miguel Lurgi & Johannes R. Björk & Cole Easson & Carmen Astudillo-García & Julie B. Olson & Patrick M. Erwin & Susanna López-Legentil & Heidi Luter & Andia Chav, 2016. "Diversity, structure and convergent evolution of the global sponge microbiome," Nature Communications, Nature, vol. 7(1), pages 1-12, September.
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    4. Cheng Cheng & Lynsey MacIntyre & Usama Ramadan Abdelmohsen & Hannes Horn & Paraskevi N Polymenakou & RuAngelie Edrada-Ebel & Ute Hentschel, 2015. "Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-21, September.
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