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Effectiveness of dasabuvir/ombitasvir/paritaprevir/ritonavir for hepatitis C virus in clinical practice: A population-based observational study

Author

Listed:
  • Maya Leventer-Roberts
  • Ariel Hammerman
  • Ilan Brufman
  • Moshe Hoshen
  • Marius Braun
  • Yaffa Ashur
  • Nicky Lieberman
  • Ran Balicer

Abstract

Background: Direct acting antivirals for hepatitis C virus have shown dramatic results in clinical trials. However, their effectiveness has yet to be demonstrated within observational cohorts which lack exclusion criteria found in randomized control trials. Aim: To determine the effectiveness of dasabuvir/ombitasvir/paritaprevir/ritonavir in achieving sustained virological response. Methods: Retrospective observational cohort study of all Clalit Health Services members with hepatitis C virus genotype 1 who were dispensed dasabuvir/ombitasvir/paritaprevir/ritonavir from January 1, 2015 to-November 31, 2015. Results: There were 564 participants during the study period. The average age was 61.9 years, 52.0% were male, and 61.5% were born Eastern/Central Europe or Central Asia. The prevalence of diabetes was 31.7% and 70.3% were overweight/obese. Cirrhosis was present in 41.0% of participants, of whom 52.8% had stage 4 fibrosis. Of the cohort, 416 (74.8%) had follow-up viral load testing at 10 or more weeks after the end of treatment. We report a sustained virological response of 98.8% among those tested. Conclusions: Treatment with dasabuvir/ombitasvir/paritaprevir/ritonavir demonstrated a near universal effectiveness in achieving a sustained virological response among HCV patients in a large cohort.

Suggested Citation

  • Maya Leventer-Roberts & Ariel Hammerman & Ilan Brufman & Moshe Hoshen & Marius Braun & Yaffa Ashur & Nicky Lieberman & Ran Balicer, 2017. "Effectiveness of dasabuvir/ombitasvir/paritaprevir/ritonavir for hepatitis C virus in clinical practice: A population-based observational study," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0176858
    DOI: 10.1371/journal.pone.0176858
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    References listed on IDEAS

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    1. Shmueli, Amir & Bendelac, Jacques & Achdut, Leah, 2007. "Who switches sickness funds in Israel?," Health Economics, Policy and Law, Cambridge University Press, vol. 2(3), pages 251-265, July.
    2. Thanthima Suwanthawornkul & Thunyarat Anothaisintawee & Abhasnee Sobhonslidsuk & Ammarin Thakkinstian & Yot Teerawattananon, 2015. "Efficacy of Second Generation Direct-Acting Antiviral Agents for Treatment Naïve Hepatitis C Genotype 1: A Systematic Review and Network Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-17, December.
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