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CO2 driven endotracheal tube cuff control in critically ill patients: A randomized controlled study

Author

Listed:
  • Gennaro De Pascale
  • Mariano Alberto Pennisi
  • Maria Sole Vallecoccia
  • Giuseppe Bello
  • Riccardo Maviglia
  • Luca Montini
  • Valentina Di Gravio
  • Salvatore Lucio Cutuli
  • Giorgio Conti
  • Massimo Antonelli

Abstract

Background: To determine the safety and clinical efficacy of an innovative integrated airway system (AnapnoGuard™ 100 system) that continuously monitors and controls the cuff pressure (Pcuff), while facilitating the aspiration of subglottic secretions (SS). Methods: This was a prospective, single centre, open-label, randomized, controlled feasibility and safety trial. The primary endpoint of the study was the rate of device related adverse events (AE) and serious AE (SAE) as a result of using AnapnoGuard (AG) 100 during mechanical ventilation. Secondary endpoints were: (1) mechanical complications rate (2) ICU staff satisfaction; (3) VAP occurrence; (4) length of mechanical ventilation; (5) length of Intensive Care Unit stay and mortality; (6) volume of evacuated subglottic secretions. Results: No difference in adverse events rate was identified between the groups. The use of AG system was associated with a significantly higher incidence of Pcuff determinations in the safety range (97.3% vs. 71%; p

Suggested Citation

  • Gennaro De Pascale & Mariano Alberto Pennisi & Maria Sole Vallecoccia & Giuseppe Bello & Riccardo Maviglia & Luca Montini & Valentina Di Gravio & Salvatore Lucio Cutuli & Giorgio Conti & Massimo Anton, 2017. "CO2 driven endotracheal tube cuff control in critically ill patients: A randomized controlled study," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0175476
    DOI: 10.1371/journal.pone.0175476
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