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Sequential monitoring of lymphocyte subsets and of T-and-B cell neogenesis indexes to identify time-varying immunologic profiles in relation to graft-versus-host disease and relapse after allogeneic stem cell transplantation

Author

Listed:
  • Cristina Skert
  • Simone Perucca
  • Marco Chiarini
  • Viviana Giustini
  • Alessandra Sottini
  • Claudia Ghidini
  • Stefano Martellos
  • Federica Cattina
  • Benedetta Rambaldi
  • Valeria Cancelli
  • Michele Malagola
  • Alessandro Turra
  • Nicola Polverelli
  • Simona Bernardi
  • Luisa Imberti
  • Domenico Russo

Abstract

T and B lymphocyte subsets have been not univocally associated to Graft-versus-host disease (GVHD) and relapse of hematological malignancies after stem cell transplantation (SCT). Their sequential assessment together with B and T cell neogenesis indexes has been not thoroughly analysed in relation to these changing and interrelated immunologic/clinic events yet.Lymphocyte subsets in peripheral blood (PB) and B and T cell neogenesis indexes were analysed together at different time points in a prospective study of 50 patients. Principal component analysis (PCA) was used as first step of multivariate analysis to address issues related to a high number of variables versus a relatively low number of patients. Multivariate analysis was completed by Fine-Gray proportional hazard regression model. PCA identified 3 clusters of variables (PC1-3), which correlated with acute GVHD: PC1 (pre-SCT: KRECs≥6608/ml, unswitched memory B 44%, CD8+TCM cells>4%; HR 1.9, p = 0.01), and PC3 (at aGVHD onset: CD4+TEMRA 69%, switched memory CD19+ = 0 cells and KRECs

Suggested Citation

  • Cristina Skert & Simone Perucca & Marco Chiarini & Viviana Giustini & Alessandra Sottini & Claudia Ghidini & Stefano Martellos & Federica Cattina & Benedetta Rambaldi & Valeria Cancelli & Michele Mala, 2017. "Sequential monitoring of lymphocyte subsets and of T-and-B cell neogenesis indexes to identify time-varying immunologic profiles in relation to graft-versus-host disease and relapse after allogeneic s," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-18, April.
    • Handle: RePEc:plo:pone00:0175337
    DOI: 10.1371/journal.pone.0175337
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