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Effectiveness of diffusion tensor imaging in differentiating early-stage subcortical ischemic vascular disease, Alzheimer’s disease and normal ageing

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  • Min-Chien Tu
  • Chung-Ping Lo
  • Ching-Feng Huang
  • Yen-Hsuan Hsu
  • Wen-Hui Huang
  • Jie Fu Deng
  • Yung-Chuan Lee

Abstract

Objective: To describe and compare diffusion tensor imaging (DTI) parameters between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer’s disease (AD) diagnosed using structuralized neuropsychiatric assessments, and investigate potential neuronal substrates related to cognitive performance. Methods: Thirty-five patients with SIVD, 40 patients with AD, and 33 cognitively normal control (NC) subjects matched by age and education level were consecutively recruited and underwent cognitive function assessments and DTI examinations. Comparisons among these three subgroups with regards to cognitive performance and DTI parameters including fractional anisotropy (FA) and mean diffusivity (MD) values were performed. Partial correlation analysis after controlling for age and education was used to evaluate associations between cognitive performance and DTI parameters. Results: With regards to cognitive performance, the patients with SIVD had lower total scores in frontal assessment battery (FAB) compared to those with AD (p

Suggested Citation

  • Min-Chien Tu & Chung-Ping Lo & Ching-Feng Huang & Yen-Hsuan Hsu & Wen-Hui Huang & Jie Fu Deng & Yung-Chuan Lee, 2017. "Effectiveness of diffusion tensor imaging in differentiating early-stage subcortical ischemic vascular disease, Alzheimer’s disease and normal ageing," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-19, April.
    • Handle: RePEc:plo:pone00:0175143
    DOI: 10.1371/journal.pone.0175143
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