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Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency

Author

Listed:
  • Magdalena Wszedybyl-Winklewska
  • Jacek Wolf
  • Ewa Swierblewska
  • Katarzyna Kunicka
  • Agnieszka Gruszecka
  • Marcin Gruszecki
  • Wieslawa Kucharska
  • Pawel J Winklewski
  • Joanna Zabulewicz
  • Wojciech Guminski
  • Michal Pietrewicz
  • Andrzej F Frydrychowski
  • Leszek Bieniaszewski
  • Krzysztof Narkiewicz

Abstract

Background: Acute hypoxia exerts strong effects on the cardiovascular system. Heart-generated pulsatile cerebrospinal fluid motion is recognised as a key factor ensuring brain homeostasis. We aimed to assess changes in heart-generated coupling between blood pressure (BP) and subarachnoid space width (SAS) oscillations during hypoxic exposure. Methods: Twenty participants were subjected to a controlled decrease in oxygen saturation (SaO2 = 80%) for five minutes. BP and heart rate (HR) were measured using continuous finger-pulse photoplethysmography, oxyhaemoglobin saturation with an ear-clip sensor, end-tidal CO2 with a gas analyser, and cerebral blood flow velocity (CBFV), pulsatility and resistive indices with Doppler ultrasound. Changes in SAS were recorded with a recently-developed method called near-infrared transillumination/backscattering sounding. Wavelet transform analysis was used to assess the relationship between BP and SAS oscillations. Results: Gradual increases in systolic, diastolic BP and HR were observed immediately after the initiation of hypoxic challenge (at fifth minute +20.1%, +10.2%, +16.5% vs. baseline, respectively; all P

Suggested Citation

  • Magdalena Wszedybyl-Winklewska & Jacek Wolf & Ewa Swierblewska & Katarzyna Kunicka & Agnieszka Gruszecka & Marcin Gruszecki & Wieslawa Kucharska & Pawel J Winklewski & Joanna Zabulewicz & Wojciech Gum, 2017. "Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-13, February.
  • Handle: RePEc:plo:pone00:0172842
    DOI: 10.1371/journal.pone.0172842
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    References listed on IDEAS

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    1. Andrzej F Frydrychowski & Arkadiusz Szarmach & Bartosz Czaplewski & Pawel J Winklewski, 2012. "Subarachnoid Space: New Tricks by an Old Dog," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-15, May.
    2. Pawel J Winklewski & Yurii Tkachenko & Kamila Mazur & Jacek Kot & Marcin Gruszecki & Wojciech Guminski & Krzysztof Czuszynski & Jerzy Wtorek & Andrzej F Frydrychowski, 2015. "Sympathetic Activation Does Not Affect the Cardiac and Respiratory Contribution to the Relationship between Blood Pressure and Pial Artery Pulsation Oscillations in Healthy Subjects," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-13, August.
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