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Economic evaluation of a guided and unguided internet-based CBT intervention for major depression: Results from a multi-center, three-armed randomized controlled trial conducted in primary care

Author

Listed:
  • Pablo Romero-Sanchiz
  • Raquel Nogueira-Arjona
  • Antonio García-Ruiz
  • Juan V Luciano
  • Javier García Campayo
  • Margalida Gili
  • Cristina Botella
  • Rosa Baños
  • Adoración Castro
  • Yolanda López-Del-Hoyo
  • Mª Ángeles Pérez Ara
  • Marta Modrego-Alarcón
  • Fermín Mayoral Cleríes

Abstract

Depression is one of the most common mental disorders and will become one of the leading causes of disability in the world. Internet-based CBT programs for depression have been classified as “well established” following the American Psychological Association criteria for empirically supported treatments. The aim of this study is to analyze the cost effectiveness at 12-month follow-up of the Internet-based CBT program “Smiling is fun” with (LITG) and without psychotherapist support (TSG) compared to usual care. The perspective used in our analysis is societal. A sample of 296 depressed patients (mean age of 43.04 years; 76% female; BDI-II mean score = 22.37) from primary care services in four Spanish regions were randomized in the RCT. The complete case and intention-to-treat (ITT) perspectives were used for the analyses. The results demonstrated that both Internet-based CBT interventions exhibited cost utility and cost effectiveness compared with a control group. The complete case analyses revealed an incremental cost-effectiveness ratio (ICER) of €-169.50 and an incremental cost-utility ratio (ICUR) of €-11389.66 for the TSG group and an ICER of €-104.63 and an ICUR of €-6380.86 for the LITG group. The ITT analyses found an ICER of €-98.37 and an ICUR of €-5160.40 for the TSG group and an ICER of €-9.91 and an ICUR of €496.72 for the LITG group. In summary, the results of this study indicate that the two Internet-based CBT interventions are appropriate from both economic and clinical perspectives for depressed patients in the Spanish primary care system. These interventions not only help patients to improve clinically but also generate societal savings.Trial Registration: clinicaltrials.gov NCT01611818

Suggested Citation

  • Pablo Romero-Sanchiz & Raquel Nogueira-Arjona & Antonio García-Ruiz & Juan V Luciano & Javier García Campayo & Margalida Gili & Cristina Botella & Rosa Baños & Adoración Castro & Yolanda López-Del-Hoy, 2017. "Economic evaluation of a guided and unguided internet-based CBT intervention for major depression: Results from a multi-center, three-armed randomized controlled trial conducted in primary care," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0172741
    DOI: 10.1371/journal.pone.0172741
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    References listed on IDEAS

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    1. Oleguer Parés-Badell & Gabriela Barbaglia & Petra Jerinic & Anders Gustavsson & Luis Salvador-Carulla & Jordi Alonso, 2014. "Cost of Disorders of the Brain in Spain," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-10, August.
    2. Don Husereau & Michael Drummond & Stavros Petrou & Chris Carswell & David Moher & Dan Greenberg & Federico Augustovski & Andrew Briggs & Josephine Mauskopf & Elizabeth Loder, 2013. "Consolidated Health Economic Evaluation Reporting Standards (CHEERS) Statement," PharmacoEconomics, Springer, vol. 31(5), pages 361-367, May.
    3. Pim Cuijpers & Tara Donker & Robert Johansson & David C Mohr & Annemieke van Straten & Gerhard Andersson, 2011. "Self-Guided Psychological Treatment for Depressive Symptoms: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-7, June.
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    1. Mario Samper-Pardo & Sandra León-Herrera & Bárbara Oliván-Blázquez & Belén Benedé-Azagra & Rosa Magallón-Botaya & Isabel Gómez-Soria & Estela Calatayud & Alejandra Aguilar-Latorre & Fátima Méndez-Lópe, 2022. "Development and Validation of a Mobile Application as an Adjuvant Treatment for People Diagnosed with Long COVID-19: Protocol for a Co-Creation Study of a Health Asset and an Analysis of Its Effective," IJERPH, MDPI, vol. 20(1), pages 1-21, December.

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