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Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis

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  • Xiaohang Wu
  • Weiyi Lai
  • Haotian Lin
  • Yizhi Liu

Abstract

Purpose: To discern and confirm genetic biomarkers that help identify populations at high risk for age-related cataract (ARC). Methods: A literature search was performed in the PubMed, Web of Science and China National Knowledge Internet databases for genetic association studies published before June 26, 2016 regarding ARC susceptibility. All genetic polymorphisms reported were systematically reviewed, followed by extraction of candidate genes/loci with sufficient genotype data in ≥3 studies for the meta-analysis. A random/fixed-effects model was used to calculate the pooled odds ratios and 95% confidence intervals to evaluate the associations considering multiple genetic models. Sensitivity analysis was also performed. Results: A total of 144 polymorphisms in 36 genes were reported in the 61 previous genetic association studies. Thereby, three polymorphisms of two genes (8-oxoguanine DNA glycosylase-1 [OGG1]; methylenetetrahydrofolate reductase NADPH [MTHFR]) in eight studies were included in the meta-analysis. Regarding the OGG1-rs1052133, the GG (OR = 1.925; 95%CI, 1.181–3.136; p = 0.009) and CG (OR = 1.384; 95%CI, 1.171–1.636; p

Suggested Citation

  • Xiaohang Wu & Weiyi Lai & Haotian Lin & Yizhi Liu, 2017. "Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-19, March.
    • Handle: RePEc:plo:pone00:0172092
    DOI: 10.1371/journal.pone.0172092
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    1. Jin Yang & Jianfeng Luo & Peng Zhou & Qi Fan & Yi Luo & Yi Lu, 2013. "Association of the Ephreceptor Tyrosinekinase-Type A2 (EPHA2) Gene Polymorphism rs3754334 with Age-Related Cataract Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-6, August.
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