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Interaction between body mass index and hormone-receptor status as a prognostic factor in lymph-node-positive breast cancer

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Listed:
  • Il Yong Chung
  • Jong Won Lee
  • Ji Sung Lee
  • Yu Rang Park
  • Yul Ha Min
  • Yura Lee
  • Tae In Yoon
  • Guiyun Sohn
  • Sae Byul Lee
  • Jisun Kim
  • Hee Jeong Kim
  • Beom Seok Ko
  • Byung Ho Son
  • Sei Hyun Ahn

Abstract

The aim of this study was to determine the relationship between the body mass index (BMI) at a breast cancer diagnosis and various factors including the hormone-receptor, menopause, and lymph-node status, and identify if there is a specific patient subgroup for which the BMI has an effect on the breast cancer prognosis. We retrospectively analyzed the data of 8,742 patients with non-metastatic invasive breast cancer from the research database of Asan Medical Center. The overall survival (OS) and breast-cancer-specific survival (BCSS) outcomes were compared among BMI groups using the Kaplan-Meier method and Cox proportional-hazards regression models with an interaction term. There was a significant interaction between BMI and hormone-receptor status for the OS (P = 0.029), and BCSS (P = 0.013) in lymph-node-positive breast cancers. Obesity in hormone-receptor-positive breast cancer showed a poorer OS (adjusted hazard ratio [HR] = 1.51, 95% confidence interval [CI] = 0.92 to 2.48) and significantly poorer BCSS (HR = 1.80, 95% CI = 1.08 to 2.99). In contrast, a high BMI in hormone-receptor-negative breast cancer revealed a better OS (HR = 0.44, 95% CI = 0.16 to 1.19) and BCSS (HR = 0.53, 95% CI = 0.19 to 1.44). Being underweight (BMI

Suggested Citation

  • Il Yong Chung & Jong Won Lee & Ji Sung Lee & Yu Rang Park & Yul Ha Min & Yura Lee & Tae In Yoon & Guiyun Sohn & Sae Byul Lee & Jisun Kim & Hee Jeong Kim & Beom Seok Ko & Byung Ho Son & Sei Hyun Ahn, 2017. "Interaction between body mass index and hormone-receptor status as a prognostic factor in lymph-node-positive breast cancer," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0170311
    DOI: 10.1371/journal.pone.0170311
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