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Fever Is Associated with Reduced, Hypothermia with Increased Mortality in Septic Patients: A Meta-Analysis of Clinical Trials

Author

Listed:
  • Zoltan Rumbus
  • Robert Matics
  • Peter Hegyi
  • Csaba Zsiboras
  • Imre Szabo
  • Anita Illes
  • Erika Petervari
  • Marta Balasko
  • Katalin Marta
  • Alexandra Miko
  • Andrea Parniczky
  • Judit Tenk
  • Ildiko Rostas
  • Margit Solymar
  • Andras Garami

Abstract

Background: Sepsis is usually accompanied by changes of body temperature (Tb), but whether fever and hypothermia predict mortality equally or differently is not fully clarified. We aimed to find an association between Tb and mortality in septic patients with meta-analysis of clinical trials. Methods: We searched the PubMed, EMBASE, and Cochrane Controlled Trials Registry databases (from inception to February 2016). Human studies reporting Tb and mortality of patients with sepsis were included in the analyses. Average Tb with SEM and mortality rate of septic patient groups were extracted by two authors independently. Results: Forty-two studies reported Tb and mortality ratios in septic patients (n = 10,834). Pearson correlation analysis revealed weak negative linear correlation (R2 = 0.2794) between Tb and mortality. With forest plot analysis, we found a 22.2% (CI, 19.2–25.5) mortality rate in septic patients with fever (Tb > 38.0°C), which was higher, 31.2% (CI, 25.7–37.3), in normothermic patients, and it was the highest, 47.3% (CI, 38.9–55.7), in hypothermic patients (Tb 75%).

Suggested Citation

  • Zoltan Rumbus & Robert Matics & Peter Hegyi & Csaba Zsiboras & Imre Szabo & Anita Illes & Erika Petervari & Marta Balasko & Katalin Marta & Alexandra Miko & Andrea Parniczky & Judit Tenk & Ildiko Rost, 2017. "Fever Is Associated with Reduced, Hypothermia with Increased Mortality in Septic Patients: A Meta-Analysis of Clinical Trials," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-15, January.
    • Handle: RePEc:plo:pone00:0170152
    DOI: 10.1371/journal.pone.0170152
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    1. Alexandra Csenkey & Gergo Jozsa & Noemi Gede & Eszter Pakai & Benedek Tinusz & Zoltan Rumbus & Anita Lukacs & Zoltan Gyongyi & Peter Hamar & Robert Sepp & Andrej A Romanovsky & Peter Hegyi & Peter Vaj, 2019. "Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-13, September.

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