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Healthcare Costs for Treating Relapsing Multiple Sclerosis and the Risk of Progression: A Retrospective Italian Cohort Study from 2001 to 2015

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  • Marcello Moccia
  • Raffaele Palladino
  • Roberta Lanzillo
  • Antonio Carotenuto
  • Cinzia Valeria Russo
  • Maria Triassi
  • Vincenzo Brescia Morra

Abstract

Background: Disease modifying treatments (DMTs) are the main responsible for direct medical costs in multiple sclerosis (MS). The current investigation aims at evaluating possible associations between healthcare costs for treating relapsing remitting MS (RRMS) and disease evolution. Methods: The present cohort study retrospectively included 544 newly diagnosed RRMS patients, prospectively followed up for 10.1±3.3 years. Costs for DMT administration and management were calculated for each year of observation. Following clinical endpoints were recorded: time to first relapse, 1-point EDSS progression, reaching of EDSS 4.0, reaching of EDSS 6.0, and conversion to secondary progressive MS (SP). Covariates for statistical analyses were age, gender, disease duration and EDSS at diagnosis. Results: At time varying Cox regression models, 10% increase in annual healthcare costs was associated with 1.1% reduction in 1-point EDSS progression (HR = 0.897; p = 0.018), with 0.7% reduction in reaching EDSS 6.0 (HR = 0.925; p = 0.030), and with 1.0% reduction in SP conversion (HR = 0.902; p = 0.006). Conclusion: Higher healthcare costs for treating MS have been associated with a milder disease evolution after 10 years, with possible reduction of long-term non-medical direct and indirect costs.

Suggested Citation

  • Marcello Moccia & Raffaele Palladino & Roberta Lanzillo & Antonio Carotenuto & Cinzia Valeria Russo & Maria Triassi & Vincenzo Brescia Morra, 2017. "Healthcare Costs for Treating Relapsing Multiple Sclerosis and the Risk of Progression: A Retrospective Italian Cohort Study from 2001 to 2015," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0169489
    DOI: 10.1371/journal.pone.0169489
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    1. Damiano Paolicelli & Sergio Iannazzo & Laura Santoni & Antonio Iaffaldano & Valentina Di Lecce & Alessia Manni & Vito Lavolpe & Carla Tortorella & Mariangela D'Onghia & Vita Direnzo & Elisa Puma & Mar, 2016. "The Cost of Relapsing-Remitting Multiple Sclerosis Patients Who Develop Neutralizing Antibodies during Interferon Beta Therapy," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-10, July.
    2. Emer Fogarty & Cathal Walsh & Christopher McGuigan & Niall Tubridy & Michael Barry, 2014. "Direct and Indirect Economic Consequences of Multiple Sclerosis in Ireland," Applied Health Economics and Health Policy, Springer, vol. 12(6), pages 635-645, December.
    3. Andrius Kavaliunas & Michael Wiberg & Petter Tinghög & Anna Glaser & Hanna Gyllensten & Kristina Alexanderson & Jan Hillert, 2015. "Earnings and Financial Compensation from Social Security Systems Correlate Strongly with Disability for Multiple Sclerosis Patients," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-11, December.
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    1. Isabela Maia Diniz & Augusto Afonso Guerra Junior & Livia Lovato Pires de Lemos & Kathiaja M Souza & Brian Godman & Marion Bennie & Björn Wettermark & Francisco de Assis Acurcio & Juliana Alvares & El, 2018. "The long-term costs for treating multiple sclerosis in a 16-year retrospective cohort study in Brazil," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-14, June.
    2. Marcello Moccia & Andrea Tajani & Rosa Acampora & Elisabetta Signoriello & Guido Corbisiero & Adriano Vercellone & Primo Sergianni & Francesca Pennino & Roberta Lanzillo & Raffaele Palladino & Antonio, 2019. "Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-12, September.

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