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DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis

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  • Lihe Dai
  • Chong Ma
  • Zhensheng Zhang
  • Shuxiong Zeng
  • Anwei Liu
  • Shijie Tang
  • Qian Ren
  • Yinghao Sun
  • Chuanliang Xu

Abstract

Background: Methylation of tumor suppressor gene promoter leads to transcription inactivation and is involved in tumorigenesis. Several studies demonstrate a potential association between the Death-Associated Protein Kinase (DAPK) gene promoter methylation and bladder cancer risk, tumor stage and histological grade. Due to inconsistent results of these studies, we performed this meta-analysis to ascertain the association. Methods: Studies were retrieved from the PubMed, Embase, Web of Science and the Cochrane Library databases. Study selection and data extraction were executed by two reviewers independently. Meta-analysis was performed using Stata 13.0 and Review Manager 5.3 software. Results: A total of 21 articles involving 15 case control and 8 case series studies were included in this meta-analysis. DAPK promoter methylation was associated with bladder cancer risk (OR: 5.81; 95%CI = 3.83–8.82, P

Suggested Citation

  • Lihe Dai & Chong Ma & Zhensheng Zhang & Shuxiong Zeng & Anwei Liu & Shijie Tang & Qian Ren & Yinghao Sun & Chuanliang Xu, 2016. "DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-15, December.
    • Handle: RePEc:plo:pone00:0167228
    DOI: 10.1371/journal.pone.0167228
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    1. Tianyi Gao & Shukui Wang & Bangshun He & Yuqin Pan & Guoqi Song & Ling Gu & Liping Chen & Zhenling Nie & Yeqiong Xu & Rui Li, 2012. "The Association of RAS Association Domain Family Protein1A (RASSF1A) Methylation States and Bladder Cancer Risk: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-6, November.
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